Trocoxil tablets from Pfizer are a new and unique treatment for arthritis in dogs. One tablet lasts for an exceptionally long period of time, so that after giving the first dose, a second dose is not given for 2 weeks, then after that one tablet is given once a month. This makes it much easier for owners to administer. It also produces a better effect in the dogs being treated. By avoiding the daily peaks and troughs of medication blood levels, a more even effect is the result. This is exceptionally good at dampening the pain response from arthritic joints, so that dogs which show disappointing result with other arthritis treatments, often do much better on Trocoxil.
What is Trocoxil?
Trocoxil is supplied as small, brown, chewable tablets (with Pfizer embossed onto the surface) containing the active ingredient mavacoxib.  Trocoxil tablets are available in strengths of 6mg, 20mg, 30mg, 75mg or 95mg. It is used in dogs over 12 months of age, where prolonged treatment is needed. The dose is 2 mg of Trocoxil per kg body weight, which should be given immediately before or with a large meal. A full course of treatment lasts for just over six months. (A total of 7 tablets, given on day 1, day 14, then every month.) After 7 tablets have been given, a period of one month should be left before another course of Trocoxil is started. A different drug, such as Rimadyl, can be given safely during this time
How Does Trocoxil Work?
Trocoxil belongs to the group of drugs known as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), which includes human drugs like ibuprofen and paracetamol. It is a modern drug so it is particularly good at suppressing inflammation in the joints, while not affecting the useful bodily processes which older NSAIDs tend to do. This means that Trocoxil is less likely to show side effects than the older drugs. (Technically it inhibits the enzyme cyclooxygenase-2 or COX-2, while having negligible effect on cyclooxygenase-1 or COX-1. ) By reducing the inflammation affecting arthritic joints, the stiffness and discomfort are less apparent, and treated dogs start to move more freely and easily. Many older dogs seem to show a new lease of life when treated with Trocoxil.
What are the Trocoxil Side Effects?
These are mostly the same for all NSAIDs. Although modern drugs like Trocoxil are very good at targeting the correct enzyme in the body, they do have some effect where it is not wanted (the cyclooxygenase-1 enzyme, and occasionally elsewhere). When this happens, the gut lining can be damaged, as can the liver or kidneys. Any bleeding disorders can be made worse, and adverse effects are more likely to be seen in dogs which are dehydrated or have a heart condition. In practical terms, dogs which seem otherwise well are very unlikely to show side effects if treated with Trocoxil, but they should be assessed by a veterinary surgeon before treatment is started. It at any time, the dog goes off its food, shows vomiting or diarrhoea, or becomes subdued and disinterested, then no more tablets should be given until these symptoms have fully resolved and the dog has been checked by a veterinary surgeon.

Most dogs can tolerate accidental overdose of Trocoxil, but great care should still be taken to avoid this. The fact that Trocoxil remains effective in the body for an extended period of time is normally very useful. However it becomes a problem if a dog has to be treated for side effects. The treatment might need to be given for an extended period too. In common with all NSAIDs, adverse reactions can sometimes occur and these can be extremely serious. Trocoxil should not be given to animals less than 12 months old, to pregnant or lactating bitches, or to dogs which appear unwell. Trocoxil is a prescription only medicine, and needs to be given under the direction or a veterinary surgeon.
If you have a dog suffering osteoarthritic pain, who needs regular medication, please come in and talk to us about whether this drug may be a suitable alternative for your pet. Trocoxil is a veterinary prescription drug only.